| Gene Symbol | SENP3 |
| Aliases | SENP3PROTEIN |
| Chromosome | 17p13.1 |
| Function | SENP3 is a SUMO-specific protease that removes SUMO (Small Ubiquitin-like Modifier) conjugates from target proteins. It plays crucial roles in regulating transcription, DNA repair, stress responses... |
| Subcellular Localization | - **Catalytic core**: Protease domain for SUMO removal - **SIM (SUMO-interacting |
| Molecular Weight | 73 kDa |
| Amino Acids | 574 aa |
| GeneCards | SENP3 |
| Human Protein Atlas | SENP3 |
| SUMO Proteins | SENP3 substrates; dysregulated SUMOylation implicated in neurodegeneration |
| SENP Family | Other deSUMOylases with overlapping and distinct functions |
| p53 | Key SENP3 substrate involved in stress responses and apoptosis |
| Nucleolus | Primary subcellular location and functional |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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