therapeutic 2,334 words KG: ent-gene-801d9596
section:therapeuticskind:therapeutictopic:parkinsons
Contents

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

🔬 Protein Info
Gene SymbolDJ-1
AliasesPARK7
Chromosome1p36.23.
Protein FamilyPfam: DJ-1/Pfpl
FunctionDJ-1 is a highly conserved protein with multiple cellular functions:
Primary ExpressionSubstantia Nigra, Hippocampus
Molecular Weight20 kDa
Amino Acids189 aa
PathwaysAlpha-Synuclein, Autophagy, Chaperone, Epigenetic, Er Stress
GeneCardsDJ-1
Human Protein AtlasDJ-1
Molecular weight~20 kDa
StructureAlpha/beta fold, dimeric
HomologsBacterial gutK, eukaryotic YajL
ModificationSite
Associated DiseasesALS, Aging, Alzheimer, Ataxia, Huntington
InteractionsMITOCHONDRIAL DYSFUNCTION, MITOPHAGY, SIRT1, MTDNA, AMPK, NRF2
KG Connections606 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.46
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.46
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.46
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.46
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.46

Knowledge Graph (2 edges)

ent-gene-801d9596 data_in benchmark_ot_ad_answer_key:PARK7
benchmark_ot_ad_answer_key:PARK7 data_in ent-gene-801d9596