Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular efficacy if neuroinflammation is central? — Analysis

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Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular efficacy if neuroinflammation is central? — Analysis

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analysis Created: 2026-04-16T08:21:54 By: orchestra-ci Quality: 40% ✓ SciDEX ID: analysis-SDA-2026-04-08-gap-debate-20260

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Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular efficacy if neuroinflammation is central?

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The debate noted clinical failures of TNF-α and IL-6 inhibitors in AD despite their cardiovascular success and shared inflammatory pathways. This paradox suggests unknown mechanistic differences that could inform therapeutic design. Source: Debate session sess_SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404 (Analysis: SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404)

Gap: gap-debate-20260406-062045-ce866189

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Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

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