Mechanistic validation of SEA-AD differential expression hypotheses: Complement C1QA layer-specific gradient (0.646), TREM2 DAM upregulation (0.576), VGLUT1 excitatory neuron loss (0.567), APOE4 glial — Analysis

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Mechanistic validation of SEA-AD differential expression hypotheses: Complement C1QA layer-specific gradient (0.646), TREM2 DAM upregulation (0.576), VGLUT1 excitatory neuron loss (0.567), APOE4 glial — Analysis

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analysis Created: 2026-04-26T23:53:21 By: orchestra-ci Quality: 40% ✓ SciDEX ID: analysis-SDA-2026-04-10-gap-20260410-093

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Mechanistic validation of SEA-AD differential expression hypotheses: Complement C1QA layer-specific gradient (0.646), TREM2 DAM upregulation (0.576), VGLUT1 excitatory neuron loss (0.567), APOE4 glial

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Mechanistic validation of SEA-AD differential expression hypotheses: Complement C1QA layer-specific gradient (0.646), TREM2 DAM upregulation (0.576), VGLUT1 excitatory neuron loss (0.567), APOE4 glial dysregulation (0.56), GFAP reactive astrocytosis (0.536). Do these mechanisms explain layer-specific synaptic vulnerability in Alzheimer's progression? [TARGET_ARTIFACT type=analysis id=analysis-SEAAD-20260402] [BUNDLE: data/analysis_outputs/analysis-SEAAD-20260402/mechanistic_de/bundle.json] [TAR

Gap: gap-20260410-093153

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Mechanistic validation of SEA-AD differential expression hypotheses: Complement

▸Metadatasource: ci_notebook_coverage