Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation

h-856feb98

**Molecular Mechanism and Rationale** The CA3-CA1 hippocampal circuit represents a fundamental neural pathway essential for episodic memory formation and consolidation, making it a critical target for Alzheimer's disease (AD) therapeutic intervention. This circuit exhibits pathological alterations early in AD progression, characterized by synaptic dysfunction, neuronal loss, and impaired plastici