Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization

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## Mechanistic Overview The hypothesis proposes that stabilizing hippocampal CA3-CA1 synaptic function through DHHC2-mediated PSD95 palmitoylation can rescue synaptic transmission in Alzheimer's disease (AD), with BDNF signaling as a key downstream effector of this structural stabilization. ## Molecular Mechanism and Rationale DHHC2 palmitoyltransferase catalyzes reversible palmitoylation of PS