Selective Acid Sphingomyelinase Modulation Therapy

h-de0d4364

## Mechanistic Overview Selective Acid Sphingomyelinase Modulation Therapy starts from the claim that modulating SMPD1 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: "**Overview** This hypothesis proposes selective pharmacological modulation of acid sphingomyelinase (ASM, encoded by SMPD1) to restore ceramide homeostasis and