TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clearance Through Astrocytic Endfoot Maintenance

h-var-2041072461

**Molecular Mechanism and Rationale** The TREM2-dependent microglial surveillance hypothesis centers on a sophisticated molecular network involving the triggering receptor expressed on myeloid cells 2 (TREM2) and its essential adapter protein DAP12 (DNAX-activation protein 12). TREM2 is a transmembrane receptor predominantly expressed on microglia in the central nervous system, functioning as a p