Locus Coeruleus-Hippocampal Circuit Protection

h-23b94ed8

## Mechanistic Overview Locus Coeruleus-Hippocampal Circuit Protection starts from the claim that modulating MAPT within the disease context of neuroscience can redirect a disease-relevant process. The original description reads: "## Mechanistic Overview Locus Coeruleus-Hippocampal Circuit Protection starts from the claim that modulating MAPT within the disease context of neuroscience can redirect

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
neuroscience	1744	±77	31-17-0	48

Ancestry (oldest → this)

(no parents — root hypothesis)

Descendants

mutate Cholinergic Basal Forebrain-Hippocampal Circuit Protection

1797 (40 matches)

crossover Dual-Circuit Tau Vulnerability Cascade

1819 (36 matches)

mutate Glymphatic-Mediated Tau Clearance Dysfunction

2189 (35 matches)

mutate Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

1688 (27 matches)

crossover SULF-Mediated Protection of Cholinergic Tau Transport Pathways

1500 (0 matches)

mutate Dopaminergic Ventral Tegmental-Striatal Circuit Protection

1500 (0 matches)

crossover Glymphatic-Cholinergic Tau Clearance Cascade

1288 (8 matches)

mutate Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated Amplification

1491 (8 matches)

mutate Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling

2058 (24 matches)

crossover GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

2215 (16 matches)

mutate Microglial TREM2-Mediated Tau Phagocytosis Impairment

1255 (4 matches)

crossover TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

2288 (12 matches)

mutate Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment

1536 (12 matches)

crossover TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clearance Thr

1500 (0 matches)

mutate Microglial Exosome-Mediated Tau Propagation

1500 (0 matches)

mutate Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling

1333 (4 matches)

mutate GluN2B-Mediated Microglial Activation and Tau Propagation

1500 (0 matches)

crossover Ketone-Primed Thalamocortical Enhancement of Glymphatic Tau Clearance

1500 (0 matches)

mutate GluN2B-Mediated Perivascular Pericyte Control of Glymphatic Tau Clearance

crossover TREM2-GluN2B Circuit: Microglial Control of Thalamocortical Oscillations and Gly

mutate GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling

1500 (0 matches)

crossover TREM2-Dependent Microglial Control of Thalamocortical-Glymphatic Tau Clearance

1500 (0 matches)

crossover TREM2-Regulated Astrocytic Calcium Dynamics Control Glymphatic Tau Clearance

mutate GluN2B-Mediated Microglial Activation and Tau Phagocytosis

mutate TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocyte Tau Clearance Net

1500 (0 matches)

mutate TREM2-Mediated Microglial Metabolic Reprogramming Accelerates Tau Pathological S

mutate TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blood-Brain Barrier Bre

1500 (0 matches)

mutate TREM2-Mediated Microglial Dysfunction Impairs Synaptic Tau Propagation Blockade