40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia

h-var-261452bfb4

## Molecular Mechanism and Rationale The core mechanism centers on ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) as a critical enzyme that converts polyunsaturated fatty acids (PUFAs) into acyl-CoA derivatives, which are subsequently incorporated into phosphatidylethanolamine (PE) membranes, creating substrates for lipid peroxidation and ferroptotic cell death. Under homeostatic conditio