TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neurodegeneration

h-var-33f643b43a

**Molecular Mechanism and Rationale** The TREM2-mediated oligodendrocyte-microglia metabolic coupling pathway represents a sophisticated intercellular communication network that maintains white matter integrity through coordinated metabolic support and debris clearance. TREM2 (Triggering Receptor Expressed on Myeloid cells 2) functions as a pattern recognition receptor exclusively expressed on mi