TREM2-Dependent Microglial Senescence Transition
h-61196ade
## Mechanistic Overview
TREM2-Dependent Microglial Senescence Transition starts from the claim that modulating TREM2 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: "**Background and Rationale** Triggering Receptor Expressed on Myeloid cells 2 (TREM2) represents one of the most significant genetic risk factors for late-onset
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| neurodegeneration | 2088 | ±68 | 55-16-0 | 71 |
Ancestry (oldest → this)
(no parents — root hypothesis)
Descendants
1507 (6 matches)
1402 (6 matches)
1485 (16 matches)
1733 (54 matches)
1395 (6 matches)
2073 (34 matches)
1263 (4 matches)
1289 (3 matches)
1381 (3 matches)
1533 (6 matches)
1500 (0 matches)
1515 (3 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)