TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegeneration

h-var-3891c45d35

**Molecular Mechanism and Rationale** The TREM2-mediated oligodendrocyte-microglia signaling axis represents a sophisticated cellular communication network essential for white matter homeostasis and repair. TREM2 (Triggering Receptor Expressed on Myeloid cells 2) functions as a pattern recognition receptor on microglia that specifically recognizes damage-associated molecular patterns (DAMPs) and