TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk

h-var-56a6156e67

**Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) pathway represents a critical molecular switch governing microglial homeostasis and their transition from neuroprotective to neurotoxic phenotypes during aging and neurodegeneration. TREM2 functions as a transmembrane receptor exclusively expressed on microglia in the central nervous system, forming