Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment

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**Molecular Mechanism and Rationale** The molecular foundation of this hypothesis centers on the disruption of the TREM2-mediated phagocytic clearance system, which normally functions as a critical surveillance mechanism for tau homeostasis in the central nervous system. Under physiological conditions, TREM2 recognizes damage-associated molecular patterns (DAMPs) including phosphatidylserine, sph