TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocyte Tau Clearance Networks
h-var-5aec85b987
**Molecular Mechanism and Rationale**
The TREM2-mediated microglial dysfunction hypothesis centers on the critical role of the triggering receptor expressed on myeloid cells 2 (TREM2) and its adaptor protein DAP12 (DNAX-activation protein 12) in orchestrating cellular clearance mechanisms and intercellular communication networks within the central nervous system. TREM2, a glycoprotein receptor ex
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| neuroscience | 1500 | ±350 | 0-0-0 | 0 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-23b94ed8
mutate · gen 2
parent: h-var-95b0f9a6bc
crossover · gen 3
parent: h-var-ce41f0efd7 × h-var-95b0f9a6bc
mutate · gen 4
parent: h-var-7c976d9fb7
Descendants
(no variants yet)