TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

h-var-66156774e7

## Mechanistic Overview TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a type I transmembrane glycoprotein predominantly expressed on microglia in the central nervous system, where it associates with the adaptor protein TYROBP (DAP12) to form a functional signaling complex. Upon ligand binding—including phospholipids, lipoproteins, and amyloid-β oligomers—TREM2 undergoes conformation