Microglial TREM2-Mediated Tau Phagocytosis Impairment
h-var-69c66a84b3
**Molecular Mechanism and Rationale**
The microglial TREM2-mediated tau phagocytosis impairment represents a complex pathological cascade involving disrupted protein-protein interactions and compromised cellular clearance mechanisms. Under physiological conditions, TREM2 functions as a pattern recognition receptor that binds to phosphatidylserine (PS) and other lipid ligands exposed on apoptotic
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| neuroscience | 1255 | ±232 | 0-4-0 | 4 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-23b94ed8
mutate · gen 2
parent: h-var-95b0f9a6bc
Descendants
(no variants yet)