CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Complement Vulnerability Maps for Synaptic Pruning

h-var-6eb97ce157

This hypothesis proposes that activity-dependent CREB signaling creates spatially distinct complement vulnerability maps by differentially regulating CD55 and CD46 expression across synaptic populations. Low-activity synapses maintain high CREB1 phosphorylation through sustained calcium influx, driving transcription of CD55 and CD46 complement regulators via CRE-binding sites in their promoters. T