Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signaling

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**Molecular Mechanism and Rationale** The activity-dependent synaptic tagging mechanism represents a sophisticated neuronal quality control system that operates through the coordinated interplay of CREB1 (cAMP response element-binding protein 1), BDNF (brain-derived neurotrophic factor), and NTRK2 (TrkB receptor) signaling cascades. At the molecular level, this process begins with neural activity