Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leading to Senescent Glial Networks

h-var-71ac892791

**Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling pathway represents a critical regulatory nexus in microglial function, operating through a sophisticated molecular cascade that becomes fundamentally altered during aging. Under physiological conditions, TREM2 associates with TYROBP (also known as DAP12) to form a functional receptor compl