TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration

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## **Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) serves as a critical orchestrator of intercellular communication between microglia and astrocytes through a sophisticated molecular signaling network that maintains central nervous system homeostasis. TREM2, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, associates with