Microglial Exosome-Mediated Tau Propagation

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**Molecular Mechanism and Rationale** The microglial exosome-mediated tau propagation hypothesis represents a paradigm shift in understanding tauopathy progression, positioning activated microglia as inadvertent facilitators rather than protective agents in tau pathology dissemination. Under physiological conditions, microglia serve as the brain's primary immune effector cells, utilizing pattern