APOE-TREM2 Ligand Availability Dysfunction in Neurodegeneration

h-var-9d0c0787a5

**Molecular Mechanism and Rationale** The APOE-TREM2 ligand availability dysfunction hypothesis centers on the critical interaction between apolipoprotein E (APOE) and the triggering receptor expressed on myeloid cells 2 (TREM2), a transmembrane immune receptor predominantly expressed on microglia in the central nervous system. Under physiological conditions, APOE functions as a high-affinity lig