TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegeneration

h-var-a09981fa01

## **Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling pathway represents a critical molecular hub orchestrating oligodendrocyte-microglia cross-talk in white matter homeostasis. TREM2 functions as a transmembrane glycoprotein exclusively expressed on microglia, forming a signaling complex with the adaptor protein TYROBP (DNAX-activating pr