TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration

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## **Molecular Mechanism and Rationale** The TREM2-mediated mitochondrial dysfunction hypothesis proposes a novel mechanistic framework where TREM2 (Triggering Receptor Expressed on Myeloid cells 2) serves as a critical regulator of mitochondrial homeostasis in microglia through direct coupling of cell surface signaling to intracellular bioenergetic pathways. Upon ligand engagement—including phos