Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling

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The activity-dependent synaptic tagging mechanism operates through coordinated interplay of CREB1, IGF1 (insulin-like growth factor 1), and IGF1R (insulin-like growth factor 1 receptor) signaling cascades. Neural activity-induced calcium influx activates CaMKIV and PKA, which phosphorylate CREB1 at serine 133, enabling binding to CRE sites in target gene promoters. Phosphorylated CREB1 initiates t