Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling

h-var-c46786d2ab

## **Molecular Mechanism and Rationale** The astrocytic-mediated tau clearance dysfunction hypothesis centers on the pathological upregulation of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) in reactive astrocytes during tauopathy progression. Under physiological conditions, TREM2 expression is primarily restricted to microglia, where it serves as a damage-associated molecular pattern