TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging

h-var-ddd5c9bcc8

**Molecular Mechanism and Rationale** The TREM2-SIRT1 metabolic senescence circuit represents a critical regulatory network that maintains microglial homeostasis through coordinated metabolic and epigenetic signaling. TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) functions as a transmembrane glycoprotein that associates with the TYROBP (TYRO protein tyrosine kinase binding protein) ada