Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance

h-var-e47f17ca3b

## Molecular Mechanism and Rationale The core molecular mechanism centers on beta-frequency entrainment driving synchronized parvalbumin-positive (PV+) interneuron firing patterns that activate astrocytic gap junction networks through ATP-mediated purinergic signaling. When PV+ basket cells fire in coordinated 20 Hz bursts, they release GABA and co-transmitters including ATP, which binds to P2Y1