TREM2-Mediated Microglial Dysfunction Impairs Synaptic Tau Propagation Blockade

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The TREM2/DAP12 signaling pathway normally functions as a critical gatekeeper preventing trans-synaptic tau propagation through specialized microglial surveillance at synaptic clefts. TREM2 receptors on microglial processes positioned at tripartite synapses detect extracellular tau oligomers released from presynaptic terminals through direct binding to tau's microtubule-binding domain. Upon tau de