APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restoration in Alzheimer's Disease

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This hypothesis proposes using transcranial focused ultrasound (tFUS) to mechanically enhance APOE4 protein lipidation specifically within hippocampal CA1 regions, thereby restoring parvalbumin (PV) interneuron function and gamma oscillations. The core mechanism leverages ultrasonic acoustic waves to disrupt APOE4's pathological domain interaction structure—the salt bridge between Arg61 and Glu255