Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease

h-var-6612521a02

**Background and Rationale** Alzheimer's disease (AD) manifests early hippocampal network dysfunction characterized by the progressive loss of gamma oscillations (30-100 Hz) that are critical for memory encoding and consolidation. Gamma rhythms emerge from the precise timing of perisomatic inhibition delivered by parvalbumin-positive (PV) fast-spiking interneurons onto CA1 pyramidal cells. These