TREM2-Astrocyte Communication in Microglial Dysfunction

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## **Molecular Mechanism and Rationale** The TREM2-astrocyte communication network represents a sophisticated intercellular signaling system that fundamentally governs microglial homeostasis and neuroinflammatory responses. TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) functions as a pattern recognition receptor exclusively expressed on microglia within the central nervous system, wher