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Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
active
paper
Created: 2026-04-17T10:19:28
By: etl-v1-backfill
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50%
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ID: 640f626a-ad3e-4ccf-a806-fbe18cc83b81
📄 Paper Details
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalçın, Kiarash Shamardani, Abigail Rogers, Rebecca Mancusi, Vrunda Trivedi et al.
Abstract
Glutamatergic neuronal activity promotes proliferation of both oligodendrocyte precursor cells (OPCs) and gliomas, including diffuse midline glioma (DMG). However, the role of neuromodulatory brainstem neurons projecting to midline structures where DMGs arise remains unexplored. Here, we demonstrate that midbrain cholinergic neuronal activity modulates OPC and DMG proliferation in a circuit-dependent manner. Optogenetic stimulation of the cholinergic pedunculopontine nucleus (PPN) promotes gliom...
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | papers |
| _schema_version | 1 |
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