🧫
Proximity proteomics of VE-cadherin interactome in lymphatic endothelial cells
active
experiment
Created: 2026-04-06T12:34:46
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-0ef2526d-9e4d-40f2-bdb6-1b8ab8d66538
🧫 Experiment Protocol
ExploratoryCDH5lymphatic endothelial cellsproposed
This study employed proximity proteomics to systematically identify and characterize the protein interactome of vascular endothelial (VE)-cadherin in lymphatic endothelial cells. The researchers investigated how the VE-cadherin interactome changes during junctional reorganization from discontinuous to continuous junctions, which was triggered by the lymphangiogenic factor adrenomedullin. The proximity proteomics approach allowed for the identification of both direct and indirect protein interactions within the spatial vicinity of VE-cadherin, providing insights into the molecular mechanisms underlying adherens junction remodeling in lymphatic vessels. The study revealed novel interactors including components involved in protein trafficking and recycling pathways.
PRIMARY OUTCOME
identification of VE-cadherin protein interactors
EXPECTED OUTCOMES
identification of novel VE-cadherin interacting proteins and understanding of junctional remodeling mechanisms
SUCCESS CRITERIA
successful identification of protein interactors and validation of their roles in junctional remodeling
PROTOCOL
proximity proteomics analysis with adrenomedullin treatment to trigger junctional reorganization
Source: PMID 39232006 ↗
🧫 Experiment Extras
PATHWAY
VE-cadherin signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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