🧫
TDP-43 mutant mouse model cGAS/STING pathway analysis
active
experiment
Created: 2026-04-06T12:28:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-62b2ebe2-1996-45ed-b23a-187423ff361f
🧫 Experiment Protocol
Validationamyotrophic lateral sclerosisTARDBPTDP-43 mutant miceproposed
Investigation of cGAS/STING pathway activation in TDP-43 mutant mice to validate the role of this innate immune signaling cascade in ALS pathology in vivo. The study examined whether pharmacologic inhibition or genetic deletion of cGAS and STING components could prevent the neuroinflammatory phenotype associated with TDP-43 mutations in the mouse model.
PRIMARY OUTCOME
neuroinflammatory cytokine profile
EXPECTED OUTCOMES
cGAS/STING inhibition reduces neuroinflammation in TDP-43 mutant mice
SUCCESS CRITERIA
Decreased inflammatory cytokine levels and reduced pathology
PROTOCOL
Analysis of TDP-43 mutant mice with pharmacologic inhibition or genetic deletion of cGAS/STING components, assessment of inflammatory markers and pathology
LINKED HYPOTHESES
Source: PMID 33031745 ↗
🧫 Experiment Extras
PATHWAY
cGAS/STING innate immune signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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