🧫
Molecular docking validation of ginger-PRMT1 interactions
active
experiment
Created: 2026-04-10T03:38:28
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-665f96b0-ef20-45cd-9b61-096f58b22720
🧫 Experiment Protocol
Exploratorygastric cancerPRMT1computational molecular dockingproposed
Molecular docking studies were performed to validate the interactions between ginger active compounds and the identified core gene PRMT1, as well as to confirm the relationship between PRMT1 and its upstream transcription factor EGR1 and downstream protein BTG2. This computational approach was used to predict binding affinities and validate the proposed signaling axis mechanisms at the molecular level.
PRIMARY OUTCOME
validation of protein-compound and protein-protein interactions
EXPECTED OUTCOMES
confirmation of favorable binding interactions supporting the proposed mechanism
SUCCESS CRITERIA
demonstration of stable binding conformations with favorable docking scores
PROTOCOL
molecular docking analysis using computational software to predict binding interactions between ginger compounds and PRMT1, and between PRMT1 and its regulatory partners EGR1 and BTG2
LINKED HYPOTHESES
Source: PMID 40446574 ↗
🧫 Experiment Extras
PATHWAY
EGR1/PRMT1/BTG2 signaling axis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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