🧫
Anti-netrin-1 antibody efficacy in EC mouse model
active
experiment
Created: 2026-04-10T14:41:11
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-6ecf51a4-53c4-45fb-a78c-f594fb7449f4
🧫 Experiment Protocol
Validationendometrial carcinomaNTN1endometrial carcinoma mouse modelproposed
Preclinical evaluation of NP137, an anti-netrin-1 antibody, in a mouse model of endometrial carcinoma. The study assessed the therapeutic efficacy of netrin-1 blockade using NP137 antibody in reducing tumor progression. Mouse tumor gene profiling was performed to evaluate the mechanism of action, revealing that NP137 induced cell death and inhibited epithelial-to-mesenchymal transition (EMT) in addition to its anti-tumor effects. This experiment provided crucial preclinical evidence supporting the therapeutic potential of netrin-1 blockade in endometrial cancer.
PRIMARY OUTCOME
tumor progression reduction
EXPECTED OUTCOMES
Reduced tumor progression, cell death induction, EMT inhibition
SUCCESS CRITERIA
Significant reduction in tumor growth and EMT markers
PROTOCOL
Treatment with anti-netrin-1 antibody (NP137) and tumor gene profiling analysis
LINKED HYPOTHESES
Source: PMID 37532934 ↗
🧫 Experiment Extras
PATHWAY
Netrin-1 signaling pathway, EMT pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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