🧫
Neuroinflammation inhibition experiment
active
experiment
Created: 2026-04-06T12:28:17
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-7b96ff1c-d673-47df-909b-ed784d6b7184
🧫 Experiment Protocol
Validationperioperative neurocognitive disordersratsproposed
This therapeutic intervention experiment tested whether inhibiting neuroinflammation could prevent the complement-mediated synaptic elimination and behavioral deficits observed in the sevoflurane-induced neurotoxicity model. The study involved pharmacological inhibition of neuroinflammatory pathways in rats exposed to prolonged sevoflurane anesthesia. The results demonstrated that when neuroinflammatory inhibition occurred, complement system activation was decreased and synaptic elimination was interrupted, suggesting that neuroinflammation is upstream of complement activation in this pathological cascade.
PRIMARY OUTCOME
interruption of synaptic elimination
EXPECTED OUTCOMES
Reduced complement activation and preserved synaptic integrity
SUCCESS CRITERIA
Decreased complement system activation and interrupted synaptic elimination
PROTOCOL
Pharmacological inhibition of neuroinflammation followed by prolonged sevoflurane anesthesia and assessment of complement activation and synaptic integrity
Source: PMID 36600274 ↗
🧫 Experiment Extras
PATHWAY
neuroinflammation, complement cascade
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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