🧫
Cell-cell interaction analysis of perivascular-microglial crosstalk
active
experiment
Created: 2026-04-06T12:26:59
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-8a79e5e3-52a5-445f-b14e-2525decb663a
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseSPP1AD mouse modelsproposed
Computational analysis of putative cell-cell interactions between perivascular cells and microglia, focusing on SPP1-mediated signaling. This experiment involved bioinformatics approaches to map potential molecular interactions and signaling pathways that mediate communication between perivascular SPP1-expressing cells and microglia. The analysis aimed to identify the molecular basis of perivascular cell-to-microglia crosstalk and understand how SPP1 functions as a key mediator in this cellular communication.
PRIMARY OUTCOME
Identification of cell-cell interaction networks
EXPECTED OUTCOMES
Mapping of SPP1-mediated perivascular-microglial communication pathways
SUCCESS CRITERIA
Identification of significant cell-cell interaction networks involving SPP1
PROTOCOL
Computational analysis of cell-cell interactions using transcriptomic data and interaction databases
LINKED HYPOTHESES
h-655c7f33· Temporal SPP1 Inhibition During Critical Windowsh-828b3729· Temporal Gating of Microglial Responsesh-cc1076c1· Cardiovascular-Neuroinflammation Crosstalk Interruptionh-seaad-51323624· Cell-Type Specific TREM2 Upregulation in DAM Microgliah-4dd0d19b· LRP1-Dependent Tau Uptake Disruption
Source: PMID 36747024 ↗
🧫 Experiment Extras
PATHWAY
perivascular-microglial cell-cell communication
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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