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GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously known AD genes (APOE, BIN1, SORL1, ADAM10, APH1B, SPI1) and 12 novel genes, with significant enrichment of protein-protein interaction networks and relevant disease pathways.
active
experiment
Created: 2026-04-27T23:41:45
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-961386cec2c4
🧫 Experiment Protocol
Genetic AssociationAlzheimer's diseaseAPOE, BIN1, SORL1, ADAM10, APH1B, SPI1, PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7humanextracted
Novel gene-level GWAS using neural networks with 80:20 train-test split; transcriptomic/proteomic expression differences validated for 10 of 12 new genes in AD vs healthy brains
PRIMARY OUTCOME
GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously known AD genes (APOE, BIN1, SORL1, ADAM10, APH1B, SPI1) and 12 novel genes, with significant enrichment of protein-protein interaction networks and relevant disease pathways.
LINKED HYPOTHESES
Source: pmid_39775791
🧫 Experiment Extras
PATHWAY
protein-protein interaction network, focal adhesion, extracellular matrix organization, Hippo signaling, cognition
MARKET PRICE
$0.50
STATUS
extracted
Prediction Markets (1 direct, 0 via hypothesis — 1 total)
Will TREM2 loss-of-function be confirmed as a primary (not merely modulatory) driver of amYES 88% · Liq $100 · active▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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