🧫
Longitudinal dietary change analysis and ADRD risk over 10 years
active
experiment
Created: 2026-04-10T22:37:16
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-a0c1b6bf-0689-4834-9191-684e04041b15
🧫 Experiment Protocol
ClinicalAlzheimer's disease and related dementiashuman patientsproposed
This sub-analysis of the same cohort examined changes in plant-based dietary patterns over a 10-year period and their association with ADRD risk. The analysis included 45,065 participants who had complete dietary data at both baseline and 10-year follow-up. Changes in dietary scores were categorized as large decrease (≥1 SD decrease), moderate decrease (0.5-1 SD decrease), stable (<0.5 SD change), moderate increase (0.5-1 SD increase), and large increase (≥1 SD increase). The primary focus was on how changes in the unhealthful plant-based diet index (uPDI) over time related to subsequent ADRD risk. This longitudinal change analysis provided insights into whether dietary modifications during middle to older age could influence dementia risk, particularly emphasizing the importance of reducing consumption of unhealthful plant foods.
PRIMARY OUTCOME
Incident Alzheimer's disease and related dementias in relation to dietary pattern changes
EXPECTED OUTCOMES
Increases in unhealthful plant-based diet scores over time were expected to increase ADRD risk, while decreases were expected to be protective
SUCCESS CRITERIA
- Prespecified primary endpoint (Incident Alzheimer's disease and related dementias in relation to dietary pattern changes) improves versus control with p < 0.05 or an equivalent corrected threshold used by the study.
- The effect size is biologically meaningful and reproduced across technical/biological replicates or the validation subset.
- Safety, data quality, and missingness remain within protocol-defined bounds so the result is interpretable rather than driven by attrition or assay failure.
PROTOCOL
1. Establish human patients cohorts for Alzheimer's disease and related dementias and predefine inclusion, exclusion, and quality-control criteria before intervention. 2. Apply the experimental manipulation described for the nominated disease mechanism, alongside matched control or comparator arms, and document dose, exposure window, and sample timing in a locked protocol log. 3. Measure Incident Alzheimer's disease and related dementias in relation to dietary pattern changes together with orthogonal secondary readouts such as molecular, imaging, behavioral, or safety endpoints that are appropriate to the title and study design. 4. Use blinded outcome assessment where feasible, prespecified statistical analysis, and replicate the core readout across biological replicates or an independent validation subset. 5. Interpret results against the baseline study rationale: This sub-analysis of the same cohort examined changes in plant-based dietary patterns over a 10-year period and their association with ADRD risk. The analysis included 45,065 participants who had complete dietary data at both baseline and 10-year follow-up. Ch
LINKED HYPOTHESES
h-0b67a9f249· Microglial priming is primarily epigenetic, with metabolic changes acting as coupled consequences or cofactorsh-ba57f3d3ed· LYTL and JIP4-dependent lysosomal remodeling may show mutant-selective amplification even when bulk phospho-Rab changesh-4682ee7fdf· Parthenolide changes ADORA2A coupling efficiency through membrane microdomain remodeling
Source: PMID 41950435 ↗
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
proposed
Prediction Markets (1 direct, 0 via hypothesis — 1 total)
Longitudinal dietary change analysis and ADRD risk over 10 years — will this experiment coYES 61% · Liq $100 · cancelled▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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