🧫
Tau depletion effects on microtubule domains in adult axons
active
experiment
Created: 2026-04-06T12:32:41
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-c582ba06-effb-4d78-9573-6bfb750ffda0
🧫 Experiment Protocol
ExploratoryMAPTadult rodent neuronsproposed
This experiment confirmed previous findings about microtubule domain organization by studying the effects of tau depletion on labile and stable microtubule domains in adult neuronal axons. The researchers documented that individual microtubules consist of distinct labile and stable domains, and investigated how experimental tau depletion affects these domains, specifically examining whether it causes selective shortening and partial stabilization of the labile domain as previously observed in juvenile neurons.
PRIMARY OUTCOME
microtubule domain organization and stability
EXPECTED OUTCOMES
selective shortening and partial stabilization of labile microtubule domains upon tau depletion
SUCCESS CRITERIA
confirmation of previous findings showing tau-dependent microtubule domain organization
PROTOCOL
experimental tau depletion followed by analysis of microtubule domain structure and dynamics
LINKED HYPOTHESES
h-23b94ed8· Locus Coeruleus-Hippocampal Circuit Protectionh-var-f687d4593b· Cholinergic Basal Forebrain-Hippocampal Circuit Protectionh-var-bc4357c8c5· Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectionh-var-8412ce00a4· Dual-Circuit Tau Vulnerability Cascadeh-var-95b0f9a6bc· Glymphatic-Mediated Tau Clearance Dysfunction
Source: PMID 40040809 ↗
🧫 Experiment Extras
PATHWAY
microtubule dynamics
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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