🧫
Microglial SIRPα expression in human Alzheimer's disease tissue
active
experiment
Created: 2026-04-10T23:10:58
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-e04a8a6c-603c-40c6-af10-a3e09f0a3423
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseSIRPαhuman brain tissueproposed
This experiment analyzed human brain tissue from patients with Alzheimer's disease to examine microglial SIRPα expression levels across different stages of disease progression. The researchers used human tissue samples to determine whether SIRPα expression in microglia changes during the course of Alzheimer's disease, providing translational relevance to their mouse model findings.
PRIMARY OUTCOME
microglial SIRPα expression levels
EXPECTED OUTCOMES
Declining microglial SIRPα expression with Alzheimer's disease progression
SUCCESS CRITERIA
Significant correlation between reduced SIRPα expression and disease progression
PROTOCOL
Analysis of microglial SIRPα expression in human brain tissue samples from Alzheimer's disease patients at different disease stages
LINKED HYPOTHESES
h_seaad_001· Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's diseaseh-var-fd2fd0825b· APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restoration in Alzheimer's Diseaseh-var-22c38d11cd· ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Diseaseh-var-6612521a02· Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitmh-4dd0d19b· LRP1-Dependent Tau Uptake Disruption
Source: PMID 33795678 ↗
🧫 Experiment Extras
PATHWAY
CD47-SIRPα signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
Prediction Markets (1 direct, 0 via hypothesis — 1 total)
Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via YES 86% · Liq $100 · resolved▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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