🧫
P2RX7 variant rs1718119 association with glucose homeostasis in Botnia cohort
active
experiment
Created: 2026-04-10T14:45:00
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-fa6a3cdb-0a11-4587-a4d2-45ee8fdd368e
🧫 Experiment Protocol
Exploratorytype 2 diabetesP2RX7human patientsproposed
A targeted genetic association study was performed in the Prevalence, Prediction, and Prevention of Diabetes in Botnia cohort (n=3504) to examine the relationship between P2RX7 polymorphisms and refined measures of glucose homeostasis. The study focused on two genomic regions (P2RX4/P2RX7 and P2RY1) and specifically analyzed the functional missense variant rs1718119 (A348T) in P2RX7. This variant was associated with increased insulin sensitivity and secretion, consistent with its known effect on increased pore function. The study provided detailed phenotyping including refined measures of glucose homeostasis beyond standard glycemic parameters.
PRIMARY OUTCOME
insulin sensitivity and secretion measures
EXPECTED OUTCOMES
association of P2RX7 variants with glucose homeostasis traits
SUCCESS CRITERIA
statistically significant associations between rs1718119 and insulin parameters
PROTOCOL
genetic association testing in targeted genomic regions with refined glucose homeostasis phenotyping
LINKED HYPOTHESES
Source: PMID 25719930 ↗
🧫 Experiment Extras
PATHWAY
purinergic signaling
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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