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bEV-mediated synaptic pruning via C1q-C3 pathway

experiment Created: 2026-04-10 22:33:25 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-a1acd0d3-8c0a-4c27-a025-0
🧫 Experiment Protocol Cell Biology
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Related Entities
C1q, C3
Metadata
experiment_typecell_biology
protocolInvestigation of bEV effects on synaptic pruning through C1q-C3 complement pathway activation
expected_outcomesbEVs cause excessive synaptic pruning via complement activation
success_criteriaDemonstration of increased synaptic loss and complement pathway activation following bEV treatment
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:33:25.643707
source_pmid40731189
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:33:25.734339'}
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (45)
mentions📖c1q80%
mentions📖C1Q Protein (Complement Component 1q)80%
mentions📖C3 — Complement Component 380%
mentions📖C3 Protein (Complement Component 3)80%
related📖c1q72%
related📖C1Q Protein (Complement Component 1q)72%
related📖C3 Protein (Complement Component 3)72%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖mechanisms60%
mentions📖Microglia60%
mentions📖Microglia60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖mechanisms54%
related📖Microglia54%
related📖Microglia54%
related🧫LPS-induced mouse model of depression with synaptic loss ana33%
related📖C333%
related📖C3 — Complement Component 333%

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