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Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden across cortex and striatum compared to cognitively normal controls, while tau PET binding did not significantly differ between groups.
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experiment
Created:
By: experiment_extractor
Quality:
50%
✓ SciDEX
ID: experiment-exp-a20c24c5d6d1
🧫 Experiment Protocol
Neuropathologyproposed
SUMMARY
Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden across cortex and striatum compared to cognitively normal controls, while tau PET binding did not significantly differ between groups.
METHODOLOGY NOTES
11C-PIB PET evaluated Aβ deposition; 18F-MK6240 PET assessed tau aggregation; participants categorized into Group 1 and Group 2 based on 18F-MK6240 uptake patterns
N = {'case': 14, 'total': 34, 'units': 'subjects', 'control': 20}tissue: cortex, striatum, medial temporal regionsspecies: homo_sapiens
Related Entities
▸Metadatasource: {'pmid': '39962560', 'type': 'paper', 'e
| source | {'pmid': '39962560', 'type': 'paper', 'extracted_by': 'llm_extraction_v1'} |
| tissue | cortex, striatum, medial temporal regions |
| species | homo_sapiens |
| summary | Using 11C-PIB PET and 18F-MK6240 PET imaging, asymptomatic ADAD mutation carriers showed significantly greater Aβ burden across cortex and striatum compared to cognitively normal controls, while tau P |
| sample_size | {'case': 14, 'total': 34, 'units': 'subjects', 'control': 20} |
| model_system | in_vivo |
| _schema_version | 1 |
| experiment_type | neuropathology |
| methodology_notes | 11C-PIB PET evaluated Aβ deposition; 18F-MK6240 PET assessed tau aggregation; participants categorized into Group 1 and Group 2 based on 18F-MK6240 uptake patterns |
| replication_status | novel |
| extraction_metadata | {'needs_review': False, 'extraction_date': '2026-04-28T06:44:08.518151+00:00', 'extraction_notes': '', 'extraction_confidence': 0.5} |
| statistical_evidence | {'p_value': None, 'test_type': 'qualitative analysis', 'effect_size': {'value': None, 'measure': 'qualitative comparison', 'direction': 'increased'}} |
📊 Evidence Profile
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0 supporting
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