🧫
Development and validation of triple knock-in humanized mice
active
experiment
Created: 2026-04-10T03:39:55
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-b16b95d5-c9e4-4975-a607-5
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T03:39:55.419330'} |
| p_value | None |
| protocol | Generation of triple knock-in mice through genetic engineering to express human versions of ACE2 (viral entry receptor), TMPRSS2 (viral entry protease), and FCGRT (neonatal Fc receptor) |
| effect_size | None |
| sample_size | None |
| source_pmid | 40020261 |
| extracted_at | 2026-04-09T20:39:55.416840 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Ability of mice to support viral infection and demonstrate physiologically relevant antibody half-life extension |
| expected_outcomes | Mice that can support SARS-CoV-2 infection and accurately model human antibody pharmacokinetics and protective immunity |
| statistical_methods | None |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
40%
Debates
0
Incoming
8
Outgoing
3
0 supporting
0 contradicting
0 neutral
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