Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model

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active

experiment Created: 2026-04-10T22:48:07 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-e53d1f4f-9628-473f-af16-5

🧫 Experiment Protocol Animal Modelproposed

N = 80

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T22:48:07.238570'}
p_value	None
protocol	Mice received D-galactose/sodium nitrite to induce AD pathology, then treated with curcumin (100 mg/kg), G. glabra (100 mg/kg), low-dose combination (50+50 mg/kg), high-dose combination (100+100 mg/kg
effect_size	43% reduction in escape latency, 28.6-40% additional IL-6 reduction
sample_size	80
source_pmid	41920384
extracted_at	2026-04-10T15:48:07.235988
_schema_version	1
experiment_type	animal_model
success_criteria	Significant reduction in escape latency, decreased inflammatory markers (IL-6, TNF-α), reduced tau pathology, and improved antioxidant defense
expected_outcomes	Synergistic improvement in cognitive function and reduction in neuroinflammation with combination therapy compared to monotherapies
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

21

Outgoing

21

0 supporting 0 contradicting 0 neutral

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💬 Discussion